“Readiness cohorts” are an innovation in clinical trial design to tackle the scarcity of time and people in drug studies. This has emerged in response to the challenges of recruiting the “right” research participants at the “right time” in the context of precision medicine. In this paper, we consider how the achievement of “readiness” aligns temporalities, biologies, and market processes of pharmaceutical innovation: how the promise of “willing bodies” in research emerges in relation to intertwined economic and biological time imperatives. (...) Drawing on long-term engagement with the field of Alzheimer’s disease prevention and interviews with researchers from academia and the pharmaceutical industry, we describe the discursive construction and practical arrangement of readiness. This paper contributes to understandings of temporal specificity, or “timing,” within prevention research and casts critical light on the way this specificity—the threshold for “trial readiness”—relates to an opaque and highly speculative drug development pipeline. Extending the study of biomedical potential, as that which holds promise but may not yet exist, we consider how absences operate in adaptive trials. By highlighting these absences, we outline an opportunity for socio-ethical research to intervene in the speculative gaps of drug development. (shrink)

In this paper, we examine the practice and promises of digital phenotyping. We build on work on the ‘data self’ to focus on a medical domain in which the value and nature of knowledge and relations with data have been played out with particular persistence, that of Alzheimer's disease research. Drawing on research with researchers and developers, we consider the intersection of hopes and concerns related to both digital tools and Alzheimer's disease using the metaphor of the ‘data shadow’. We (...) suggest that as a tool for engaging with the nature of the data self, the shadow is usefully able to capture both the dynamic and distorted nature of data representations, and the unease and concern associated with encounters between individuals or groups and data about them. We then consider what the data shadow ‘is’ in relation to ageing data subjects, and the nature of the representation of the individual's cognitive state and dementia risk that is produced by digital tools. Second, we consider what the data shadow ‘does’, through researchers and practitioners’ discussions of digital phenotyping practices in the dementia field as alternately empowering, enabling and threatening. (shrink)

ch. 1. A-L -- ch. 2. M-S -- ch. 3. T-I︠A︡.

The essays in this collection address different aspects of Dewey's philosophy of logic, from his work at the beginning of the twentieth century to the culmination of his logical thought in the 1938 volume, Logic: The Theory of Inquiry.

Brain-centered theories of consciousness seem to face insuperable difficulties. While some philosophers now doubt that the hard problem of consciousness will ever be solved, others call for radically new approaches to conscious experience. In this article I resurrect a largely forgotten approach to consciousness known as neorealism. According to neorealism, consciousness is merely a part, or cross-section, of the environment. Neorealism implies that all conscious experiences, veridical or otherwise, exist outside of the brain and are wholly independent of being perceived (...) or not; nonveridical perceptions of the environment over an arbitrarily short period of time are supposed to be objective constituents of the environment over a more extended time scale. I argue here that neorealism fares at least as well as brain-centered theories of consciousness on a number of fundamental issues. On one fundamental issue—the nature of the relation between veridical and nonveridical perceptions—neorealism outperforms its competitors. (shrink)

The adventurous hero Indiana Jones makes his long-awaited return to theaters this summer! Filled with the intrigue and drama characteristic of all the classic Indiana Jones films, the fourth release is all brought to life by an incredible soundtrack. Selections from Indiana Jones and the Kingdom of the Crystal Skull features popular music from the film, as composed by Academy Award winner John Williams, plus 8 pages of color artwork straight from the movie. This book is part of an instrumental (...) series arranged for Flute, Clarinet, Alto Sax, Tenor Sax, Trumpet, Horn in F, and Trombone. The arrangements are completely compatible with each other and can be played together as solos. Each book contains a carefully edited part that is appropriate for the Level 2–3 player, and a fully orchestrated accompaniment CD. The CD includes a demo track of each song, which features a live instrumental performance, followed by a play-along track. A piano accompaniment book (optional) is also available. It includes a CD that features various instrument demo tracks from the series. Titles include: *Raiders March* *The Adventures of Mutt* *The Journey to Akator* *Marion’s Theme* *Irina’s Theme*. (shrink)

Contemporary society, according to Centore, is dominated by a post-modern philosophical world-view. Lacking until now, from the many works that have been written on post-modernism, is one that scrutinizes its fundamental assumptions and presuppositions. Being and Becoming attempts to fill this need by synthesizing the key developments in contemporary post-modernism. By taking the reader through the various historical periods and developments which have led to the current situation, Centore shows what is now taken for granted by the vast majority of (...) people is not necessary for either philosophical or theological reasons. (shrink)

In this book a distinguished group of environmental experts argues that in order to solve global environmental problems, we must view them in a broad interdisciplinary perspective that recognizes the relations—the interconnected circle—among ecology, economics, and ethics. Currently the circle is broken, they say, because environmental policy is decided on short-term estimations of material that take little account of the economic or moral burdens that will be borne by future generations if we deplete our resources now. We must, assert the (...) authors, have a better knowledge of the science underlying our environmental problems, we must understand their causes and consequences in relation to our economic and political systems, and we must recognize that an effective response will require a shift in a technologically oriented society’s ethical attitude toward the natural environment. The authors address a wide range of concerns from global atmospheric degradation and spreading toxification of the environment to loss of forests and massive species extinctions. They offer to general readers, students, and professionals practical assessments and remedies for many of these problems. They suggest, for example, mechanisms that provide economic incentives for conservation; engineering and technical adaptations to use resources more effectively and dispose of waste products; better economic accounting procedures for measuring the real environmental costs of our depletion of natural resources; and a remodeled education system that better prepares us to see each individual’s responsibility to the environment. (shrink)